Chemo- and Site-Selective Electro-Oxidative Alkane Fluorination by C(sp³ )-H Cleavage.

ABSTRACT: Electrochemical fluorinations of C(sp³ )-H bonds with a nucleophilic fluoride source have been accomplished in a chemo- and site-selective fashion, avoiding the use of electrophilic F⁺ sources and stoichiometric oxidants. The introduced metal-free strategy exhibits high functional group tolerance, setting the stage for late-stage fluorinations of biorelevant motifs. The synthetic utility of the C(sp³ )-H fluorination was reflected by subsequent one-pot arylation of the generated benzylic fluorides.

SUBMITTER: Stangier M 

PROVIDER: S-EPMC9804291 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature