CD169⁺ subcapsular sinus macrophage-derived microvesicles are associated with light zone follicular dendritic cells.

ABSTRACT: Follicular dendritic cells (FDCs) are a specialized type of stromal cells that exclusively reside in B-cell follicles. When inflammation occurs, the FDC network is reorganized to support germinal center (GC) polarization into the light zone (LZ) and dark zone (DZ). Despite the indispensable role of FDCs in supporting humoral responses, the FDC regulatory requirements remain incompletely defined. In this study, we unexpectedly observed an accumulation of CD169⁺ subcapsular sinus macrophage (SSM)-derived microvesicles (MVs) in the B-cell zone, which were tightly associated with the FDC network. Interestingly, a selective deposition of CD169⁺ MVs was detected in both GC LZ FDCs in secondary follicles and on predetermined LZ FDCs in primary follicles. The ablation of CD16

SUBMITTER: Chen X 

PROVIDER: S-EPMC9804338 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature