Calcium inhibits penetration of Alzheimer's Aβ₁ -₄₂ monomers into the membrane.

ABSTRACT: Calcium ion regulation plays a crucial role in maintaining neuronal functions such as neurotransmitter release and synaptic plasticity. Copper (Cu²⁺ ) coordination to amyloid-β (Aβ) has accelerated Aβ_1-42 aggregation that can trigger calcium dysregulation by enhancing the influx of calcium ions by extensive perturbing integrity of the membranes. Aβ_1-42 aggregation, calcium dysregulation, and membrane damage are Alzheimer disease (AD) implications. To gain a detail of calcium ions' role in the full-length Aβ_1-42 and Aβ_1-42 -Cu²⁺ monomers contact, the cellular membrane before their aggregation to elucidate the neurotoxicity mechanism, we carried out 2.5 μs extensive molecular dynamics simulation (MD) to rigorous explorations o

SUBMITTER: Boopathi S 

PROVIDER: S-EPMC9804374 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature