Epidemiological cut-off values for itraconazole and ravuconazole for Madurella mycetomatis, the most common causative agent of mycetoma.

ABSTRACT:

Background

Eumycetoma is a neglected tropical disease. It is a chronic inflammatory subcutaneous infection characterised by painless swellings which produce grains. It is currently treated with a combination of itraconazole and surgery. In an ongoing clinical study, the efficacy of fosravuconazole, the prodrug of ravuconazole, is being investigated. For both itraconazole and ravuconazole, no clinical breakpoints or epidemiological cut-off values (ECV) to guide treatment are currently available.

Objective

To determine tentative ECVs for itraconazole and ravuconazole in Madurella mycetomatis, the main causative agent of eumycetoma.

Materials and methods

Minimal inhibitory concentrations (MICs) for itraconazole and ravuconazole were determined in 131 genetically diverse

SUBMITTER: Nyuykonge B 

PROVIDER: S-EPMC9804462 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature