Clinical and metabolic imaging features of late-onset and early-onset posterior cortical atrophy.

ABSTRACT:

Background and purpose

Late-onset (LO) and early-onset (EO) dementia show neurobiological and clinical differences. Clinical and ¹⁸ fluoro-deoxy-glucose positron emission tomography (FDG-PET) features of LO and EO posterior cortical atrophy (LO_PCA, EO_PCA), the visual variant of Alzheimer's disease (AD), were compared. LO_PCA patients were also compared with a group of patients with LO typical AD (tAD).

Methods

Thirty-seven LO_PCA patients (onset age ≥ 65 years), 29 EO_PCA patients and 40 tAD patients who all underwent a standard neuropsychological battery were recruited; PCA patients were also assessed for the presence of posterior signs and symptoms. Brain FDG-PET was available in 32 LO_PCA cases, 23 EO_PCA cases and all tAD cases, and their scans were compared

SUBMITTER: Isella V 

PROVIDER: S-EPMC9804481 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature