Pentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects.

ABSTRACT:

Background and purpose

Recently pentoxifylline, a non-selective phosphodiesterase inhibitor and adenosine receptor antagonist, has attracted much interest for the treatment of the increased vascular resistance and endothelial dysfunction in pre-eclampsia. We therefore investigated the placental transfer, vascular effects and anti-inflammatory actions of pentoxifylline in healthy and pre-eclamptic human placentas.

Experimental approach

The placental transfer and metabolism of pentoxifylline were studied using ex vivo placenta perfusion experiments. In wire myography experiments with chorionic plate arteries, pentoxifyllines vasodilator properties were investigated, focusing on the cGMP and cAMP pathways and adenosine receptors. Its effects on inflammatory factors were also st

SUBMITTER: Broekhuizen M 

PROVIDER: S-EPMC9804511 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature