CFTR gene variants, air pollution, and childhood asthma in a California Medicaid population.

ABSTRACT: Carriers of the cystic fibrosis transmembrane conductance regulator (CFTR) gene ("carriers") have been found to have an increased risk of persistent asthma. However, it is unclear at what level of CFTR function this risk exists and whether it is modified by asthmogens, such as air pollution. We conducted a retrospective cohort study of children born in California between July 2007 and December 2013, linking CFTR genotype data from the California newborn screening program to Medicaid claims records through March 17, 2020 to identify asthma cases, and to air pollution data from CalEnviroScreen 3.0 to identify levels of particulate matter with diameter 2.5 microns or smaller (PM_2.5 ). Log-binomial regression models for asthma risk were fitted, adjusting for race/ethnicity and sex.

SUBMITTER: Thilakaratne R 

PROVIDER: S-EPMC9804556 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature