Common genetic variants associated with melanoma risk or naevus count in patients with wildtype MC1R melanoma.

ABSTRACT:

Background

Hypomorphic MC1R variants are the most prevalent genetic determinants of melanoma risk in the white population. However, the genetic background of patients with wildtype (WT) MC1R melanoma is poorly studied.

Objectives

To analyse the role of candidate common genetic variants on the melanoma risk and naevus count in Spanish patients with WT MC1R melanoma.

Methods

We examined 753 individuals with WT MC1R from Spain (497 patients and 256 controls). We used OpenArray reverse-transcriptase polymerase chain reaction to genotype a panel of 221 common genetic variants involved in melanoma, naevogenesis, hormonal pathways and proinflammatory pathways. Genetic models were tested using multivariate logistic regression models. Nonparametric multifactor dimensionality r

SUBMITTER: Calbet-Llopart N 

PROVIDER: S-EPMC9804579 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature