Anticoagulant rodenticide blood-clotting dose-responses and resistance factors for Tyrosine139Cysteine (Y139C) heterozygous- and homozygous-resistant house mice (Mus musculus).

ABSTRACT:

Background

The house mouse (Mus musculus) is a globally distributed rodent pest species against which anticoagulant rodenticides are widely used for the protection of human and animal health and the conservation of threatened wildlife. Anticoagulant-resistant house mice have been known for more than half a century. A house mouse strain was developed in the laboratory that was homozygous resistant for the single nucleotide polymorphism (SNP) Tyrosine139Cysteine (Y139C) and, subsequently, heterozygous resistant animals were produced from this strain by crossing with the homozygous susceptible strain.

Results

Using blood clotting response tests, resistance factors at the ED₅₀ level in the homozygous resistant strain for the first-generation anticoagulants warfarin, c

SUBMITTER: Baxter MA 

PROVIDER: S-EPMC9804629 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature