Endosomal trafficking and related genetic underpinnings as a hub in Alzheimer's disease.

ABSTRACT: Genetic studies support the amyloid cascade as the leading hypothesis for the pathogenesis of Alzheimer's disease (AD). Although significant efforts have been made in untangling the amyloid and other pathological events in AD, ongoing interventions for AD have not been revealed efficacious for slowing down disease progression. Recent advances in the field of genetics have shed light on the etiology of AD, identifying numerous risk genes associated with late-onset AD, including genes related to intracellular endosomal trafficking. Some of the bases for the development of AD may be explained by the recently emerging AD genetic "hubs," which include the processing pathway of amyloid precursor protein and the endocytic pathway. The endosomal genetic hub may represent a common pathway through w

SUBMITTER: Limone A 

PROVIDER: S-EPMC9804649 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature