Long-term joint outcomes in adolescents with moderate or severe haemophilia A.

ABSTRACT:

Introduction

Favourable joint outcomes are expected with modern haemophilia A (HA) management. Evaluation of long-term treatment outcomes is hampered by the delay between bleeding episodes during childhood and resulting joint outcomes in adulthood.

Aim

To measure the long-term joint health of adolescents with moderate and severe HA, according to severity and inhibitor status.

Methods

Pilot cross-sectional study of five European PedNet centres in moderate and severe HA patients aged 10-19 years. Structured assessment of joint status by physical examination (HJHS) and ultrasound (HEAD-US).

Results

In total, 141 HA patients were evaluable, 100 without inhibitors (81 severe, 19 moderate HA), and 41 severe HA with current/past inhibitors. On physical examination, 12

SUBMITTER: Schmidt DE 

PROVIDER: S-EPMC9804743 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature