Identifying the landscape of developmental toxicity new approach methodologies.

ABSTRACT:

Background

The dynamics and complexities of in utero fetal development create significant challenges in transitioning from lab animal-centric developmental toxicity testing methods to assessment strategies based on new approach methodologies (NAMs). Nevertheless, considerable progress is being made, stimulated by increased research investments and scientific advances, such as induced pluripotent stem cell-derived models. To help identify developmental toxicity NAMs for toxicity screening and potential funding through the American Chemistry Council's Long-Range Research Initiative, a systematic literature review was conducted to better understand the current landscape of developmental toxicity NAMs.

Methods

Scoping review tools were used to systematically survey the literatur

SUBMITTER: Becker RA 

PROVIDER: S-EPMC9804744 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature