Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition.

ABSTRACT: Olive tree leaves are an abundant source of bioactive compounds with several beneficial effects for human health, including a protective role against many types of cancer. In this study, we investigated the effect of an extract, obtained from olive tree (Olea europaea L.) leaves (OLE), on proliferation, invasion, and epithelial to mesenchymal transition (EMT) on metastatic melanoma, the highly aggressive form of skin cancer and the deadliest diseases. Our results demonstrated that OLE inhibited melanoma cells proliferation through cell cycle arrest and induction of apoptotic cell death. Moreover, OLE suppressed the migration, invasion, and colonies formation of human melanoma cells. Similar to our in vitro findings, we demonstrated that the oral administration of OLE inhibited cutaneous tu

SUBMITTER: De Cicco P 

PROVIDER: S-EPMC9804751 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature