Gestational diabetes mellitus, epigenetic age and offspring metabolism.

ABSTRACT:

Aims

No reports examine the relationship between in-utero exposure to gestational diabetes mellitus (GDM), offspring epigenetic age acceleration (EAA), and offspring insulin sensitivity.

Methods

Using data from a cohort study, we examined associations between GDM in-utero exposure and offspring EAA at approximately 10 years of age, using separate regression models adjusting for offspring chronological age and sex. We also examined associations between EAA with updated homeostasis model assessment of insulin sensitivity and secretion (HOMA2-S and HOMA2-β) measured at approximately 10 and 16 years of age, using mixed linear regression models accounting for repeated measures after adjustment for offspring chronological age and sex.

Results

Compared to unexposed offspring

SUBMITTER: Kim C 

PROVIDER: S-EPMC9804757 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature