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Boosting the Enantioselectivity of Conjugate Borylation of α,β-Disubstituted Cyclobutenones with Monooxides of Chiral C₂ -Symmetric Bis(phosphine) Ligands.

ABSTRACT: Chiral bis(phosphine) monooxides (BPMOs) derived from C₂ -symmetric bis(phosphines) have been found to induce superior levels of enantioselection in copper-catalyzed conjugate borylation of α,β-disubstituted cyclobutenones. More precisely, enantiomeric excesses as well as chemical yields are exceedingly high with (R,R)-Bozphos as the chiral ligand while these values are low with parent (R,R)-Me-Duphos. A similar yet less pronounced effect was seen in the corresponding 1,6-addition to para-quinone methides.

SUBMITTER: Cui M

PROVIDER: S-EPMC9804767 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Dataset Information

Boosting the Enantioselectivity of Conjugate Borylation of α,β-Disubstituted Cyclobutenones with Monooxides of Chiral C₂ -Symmetric Bis(phosphine) Ligands.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Boosting the Enantioselectivity of Conjugate Borylation of α,β-Disubstituted Cyclobutenones with Monooxides of Chiral C2 -Symmetric Bis(phosphine) Ligands.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Boosting the Enantioselectivity of Conjugate Borylation of α,β-Disubstituted Cyclobutenones with Monooxides of Chiral C₂ -Symmetric Bis(phosphine) Ligands.