GABA_B receptor agonist baclofen promotes central nervous system remyelination.

ABSTRACT: Promoting remyelination is considered as a potential neurorepair strategy to prevent/limit the development of permanent neurological disability in patients with multiple sclerosis (MS). To this end, a number of clinical trials are investigating the potential of existing drugs to enhance oligodendrocyte progenitor cell (OPC) differentiation, a process that fails in chronic MS lesions. We previously reported that oligodendroglia express GABA_B receptors (GABA_B Rs) both in vitro and in vivo, and that GABA_B R-mediated signaling enhances OPC differentiation and myelin protein expression in vitro. Our goal here was to evaluate the pro-remyelinating potential of GABA_B R agonist baclofen (Bac), a clinically approved drug to treat spasticity in patients wi

SUBMITTER: Serrano-Regal MP 

PROVIDER: S-EPMC9804779 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature