Excessive inflammatory response to infection in experimental peri-implantitis: Resolution by Resolvin D2.

ABSTRACT:

Aim

The aetiology and pathogenesis of peri-implantitis are currently under active research. This study aimed to dissect the pathogenesis of murine experimental peri-implantitis and assess Resolvin D2 (RvD2) as a new treatment modality.

Materials and methods

Four weeks following titanium implant insertion, mice were infected with Porphyromonas gingivalis using single or multiple oral lavages. RvD2 was administrated following infection, and tissues were analysed using flow cytometry, quantitative RT-PCR, taxonomic profiling, and micro-computed tomography.

Results

Repeated infections with Pg resulted in microbial dysbiosis and a higher influx of innate and adaptive leukocytes to the peri-implant mucosa (PIM) than to gingiva surrounding the teeth. This was accompanied by

SUBMITTER: Heyman O 

PROVIDER: S-EPMC9804794 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature