Optimizing the management of analytical interferences affecting red blood cells on XN-10 (Sysmex®).

ABSTRACT:

Introduction

Interferences on red blood cells (RBCs) measurement and the associated parameters in haematology analyzers are very common. Many sources of interferences are described but their management remains uncertain depending on the measurement system; we aimed at developing an optimized scheme allowing the accurate management of most interferences affecting RBCs, based on the alternative "optical" parameters from SYSMEX XN-10.

Methods

Samples from 12 groups of relevant interferences were analysed and compared with a control group allowing (1) the determination of deviation thresholds beyond which an interference is likely, and (2) the development of two flowcharts for their subsequent management. These flowcharts were then evaluated among a bank of retrospective typical

SUBMITTER: Henry S 

PROVIDER: S-EPMC9804823 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature