Limited time-specific and longitudinal effects of depressive and manic symptoms on cognition in bipolar spectrum disorders.

ABSTRACT:

Objectives

Previous research suggests that cognitive performance worsens during manic and depressed states in bipolar disorder (BD). However, studies have often relied upon between-subject, cross-sectional analyses and smaller sample sizes. The current study examined the relationship between mood symptoms and cognition in a within-subject, longitudinal study with a large sample.

Methods

Seven hundred and seventy-three individuals with BD completed a neuropsychological battery and mood assessments at baseline and 1-year follow-up. The battery captured eight domains of cognition: fine motor dexterity, visual memory, auditory memory, emotion processing, and four aspects of executive functioning: verbal fluency and processing speed; conceptual reasoning and set shifting; process

SUBMITTER: Easter RE 

PROVIDER: S-EPMC9804834 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature