Homolytic N-S Bond Cleavage in Vinyl Triflimides Enabled by Triplet-Triplet Energy Transfer.

ABSTRACT: Vinyl triflimides are a new compound class with unknown reactivity. A computational analysis identified homolytic cleavage of the N-Tf bond induced by triplet-triplet energy transfer (EnT) as a highly interesting reaction type that might be accessible. A combination of experimental and mechanistic work verified this hypothesis and proved the generated radicals to be amenable to radical-radical coupling. Thereby, vinyl triflimides were transformed into a range of α-quaternary, β-trifluoromethylated amines in a 1,2-difunctionalization reaction with no need for external CF₃ reagents.

SUBMITTER: Strauch C 

PROVIDER: S-EPMC9804857 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature