Altered Medial Prefrontal Connectivity in Parkinson's Disease Patients with Somatic Symptoms.

ABSTRACT:

Background

The high co-occurrence of somatic symptom disorder (SSD) in Parkinson's disease (PD) patients suggests overlapping pathophysiology. However, little is known about the neural correlates of SSD and their possible interactions with PD. Existing studies have shown that SSD is associated with reduced task-evoked activity in the medial prefrontal cortex (mPFC), a central node of the default-mode network (DMN). SSD is also associated with abnormal γ-aminobutyric acid (GABA) content, a marker of local inhibitory tone and regional hypoactivity, in the same area when SSD co-occurs with PD.

Objectives

To disentangle the individual and shared effects of SSD and PD on mPFC neurotransmission and connectivity patterns and help disclose the neural mechanisms of comorbidity in the

SUBMITTER: Delli Pizzi S 

PROVIDER: S-EPMC9804911 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature