Association of Phenotypic Aging Marker with comorbidities, frailty and inflammatory markers in people living with HIV.

ABSTRACT:

Background

Aging characteristics in people living with HIV (PLWH) are heterogeneous, and the identification of risk factors associated with aging-related comorbidities such as neurocognitive impairment (NCI) and frailty is important. We evaluated predictors of novel aging markers, phenotypic age (PhenoAge) and phenotypic age acceleration (PAA) and their association with comorbidities, frailty, and NCI.

Methods

In a cohort of PLWH and age- and sex-matched HIV-negative controls, we calculated PhenoAge using chronological age and 9 biomarkers from complete blood counts, inflammatory, metabolic-, liver- and kidney-related parameters. PAA was calculated as the difference between chronological age and PhenoAge. Multivariate logistic regression models were used to identify the fact

SUBMITTER: Han WM 

PROVIDER: S-EPMC9805022 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature