M6A regulator-mediated methylation modification patterns and immune microenvironment infiltration characterization in osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is a common disease in orthopedics. RNA N6-methyladenosine (m6A) exerts an essential effect in a variety of biological processes in the eukaryotes. In this study, we determined the effect of m6A regulators in the OA along with performing the subtype classification. Differential analysis of OA and normal samples in the database of Gene Expression Omnibus identified 9 significantly differentially expressed m6A regulators. These regulators were monitored by a random forest algorithm so as to evaluate the risk of developing OA disease. On the basis of these 9 moderators, a nomogram was established. The results of decision curve analysis suggested that the patients could benefit from a nomogram model. The OA sample was classified as 2 m6A models through a consensus clusterin

SUBMITTER: Hu S 

PROVIDER: S-EPMC9805027 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature