Association analysis of LHCGR variants and polycystic ovary syndrome in Punjab: a case-control approach.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder that affects women at their child bearing age. The exact etiology is uncertain, however the involvement of multiple genes and environmental interactions has been proposed for the advancement of PCOS. The aim of present study was to evaluate the association of LHCGR variants (rs2293275 and rs12470652) with PCOS in Punjab.

Methods

The present case-control study comprised a total of 743 women (421 PCOS cases and 322 healthy controls). Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism technique (PCR-RFLP). Biochemical analysis was carried out to measure the levels of cholesterol, High-density lipoprotein (HDL), Low-density lipoprotein (LDL), Very low-den

SUBMITTER: Singh S 

PROVIDER: S-EPMC9805054 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature