Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands.

ABSTRACT: The cation nonselective channel TRPM8 is activated by multiple stimuli, including moderate cold and various chemical compounds (i.e., menthol and icilin [Fig. 1], among others). While research continues growing on the understanding of the physiological involvement of TRPM8 channels and their role in various pathological states, the information available on its activation mechanisms has also increased, supported by mutagenesis and structural studies. This review compiles known information on specific mutations of channel residues and their consequences on channel viability and function. Besides, the comparison of sequence of animals living in different environments, together with chimera and mutagenesis studies are helping to unravel the mechanism of adaptation to different temperatures. Th

SUBMITTER: Plaza-Cayon A 

PROVIDER: S-EPMC9805079 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature