Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity.

ABSTRACT:

Background

The variation in multiple sclerosis (MS) disease severity is incompletely explained by genetics, suggesting genetic and environmental interactions are involved. Moreover, the lack of prognostic biomarkers makes it difficult for clinicians to optimise care. DNA methylation is one epigenetic mechanism by which gene-environment interactions can be assessed. Here, we aimed to identify DNA methylation patterns associated with mild and severe relapse-onset MS (RMS) and to test the utility of methylation as a predictive biomarker.

Methods

We conducted an epigenome-wide association study between 235 females with mild (n = 119) or severe (n = 116) with RMS. Methylation was measured with the Illumina methylationEPIC array and analysed using logistic regression. To generate

SUBMITTER: Campagna MP 

PROVIDER: S-EPMC9805090 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature