Integrative analysis of genomic and exposomic influences on youth mental health.

ABSTRACT:

Background

Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures - that is, the exposome - is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study.

Methods

Using novel GREML-based approaches, we model the variance in internalizing and externalizing symptoms explained by additive and interactive influences from the genome (G) and modeled exposome (E) co

SUBMITTER: Choi KW 

PROVIDER: S-EPMC9805149 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature