Maternal micronutrient deficiency and congenital heart disease risk: A systematic review of observational studies.

ABSTRACT:

Background

Congenital anomalies affect over 2% of pregnancies, with congenital heart disease (CHD) the most common. Understanding of causal factors is limited. Micronutrients are essential trace elements with key roles in growth and development. We aimed to investigate whether maternal micronutrient deficiencies increase the risk of fetal CHD through systematic review of published literature.

Method

We performed a systematic review registered at PROSPERO as CRD42021276699. Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library were searched from their inception until September 7, 2021. Case control trials were included with a population of biological mothers of fetuses with and without CHD. The exposure was maternal micronutrient level measured in pregnancy or the postpartum period

SUBMITTER: Mires S 

PROVIDER: S-EPMC9805156 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature