SPP1 is a prognostic related biomarker and correlated with tumor-infiltrating immune cells in ovarian cancer.

ABSTRACT:

Background

Secreted phosphoprotein 1 (SPP1) plays a vital role in tumor progression of multiple cancer types However, it still awaits further exploration whether SPP1 is a bystander or an actual player in the modulation of immune infiltration in ovarian cancer.

Methods

In this study, the expression level of SPP1 was identified by Oncomine, GEPIA and TIMER databases, and the result of SPP1 immumohistochemical staining was acquired by The HPA database. The impact of SPP1 expression level on the clinical outcome of ovarian cancer patients were evaluated via Kaplan-Meier Plotter and PrognoScan dataset. Immune infiltration analyses were conducted using TIMER and TISIDB dataset. In addition, Functional enrichment analyses were performed with Metascape and GeneMANIA database. To ve

SUBMITTER: Gao W 

PROVIDER: S-EPMC9805166 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature