Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo.

ABSTRACT: Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These materials are thought to increase therapeutic outcome and improve current cancer management. Due to their size, nanomedicines target tumors passively. Thus, they can be used for drug delivery purposes. Bioorthogonal chemistry allows for a pretargeting approach. Higher target-to-background drug accumulation ratios can be achieved. Pretargeting can also be used to induce internalization processes or trigger controlled drug release. Colloidal gold nanoparticles (AuNPs) have attracted widespread interest as drug delivery vectors within the last decades. Here, we demonstrate for the first time the possibility to successfully ligate AuNPs in vivo

SUBMITTER: Poulie CBM 

PROVIDER: S-EPMC9805177 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature