Cotinine levels influence the risk of rupture of brain aneurysms.

ABSTRACT: Cotinine, the primary metabolite of nicotine, is currently regarded as the best biomarker of tobacco smoke exposure. We aim to assess whether cotinine levels are associated with (1) intracranial aneurysm and (2) intracranial aneurysm rupture.

Methods

We performed a single-center case-control study. Cases were consecutive patients admitted with diagnosis of brain aneurysm (ruptured or unruptured). We randomly selected controls without intracranial aneurysm from the same source population that produced the cases. Smoking data were collected by questionnaire, and serum levels of cotinine were used as an objective measure of nicotine exposure. Logistic regression models were used to assess the relationship between cotinine levels and aneurysm rupture.

Results

We included 86 patie

SUBMITTER: Missori P 

PROVIDER: S-EPMC9805191 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature