Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation.

ABSTRACT:

Background

Cardiac surgery and cardiopulmonary bypass induce a substantial immune and inflammatory response, the overactivation of which is associated with significant pulmonary, cardiovascular, and neurologic complications. Commensurate with the immune and inflammatory response are changes in the heart and vasculature itself, which together drive postoperative complications through mechanisms that are poorly understood. Longitudinal DNA methylation profiling has the potential to identify changes in gene regulatory mechanisms that are secondary to surgery and to identify molecular processes that predict and/or cause postoperative complications. In this study, we measure DNA methylation in preoperative and postoperative whole blood samples from 96 patients undergoing cardiac surgery

SUBMITTER: Fischer MA 

PROVIDER: S-EPMC9805211 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature