Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms.

ABSTRACT: Since ancient times, plants have been an extensive reservoir of bioactive compounds with therapeutic interest for new drug development and clinical application. Cucurbitacins are a compelling example of these drug leads, primarily present in the plant kingdom, especially in the Cucurbitaceae family. However, these natural compounds are also known in several genera within other plant families. Beyond the Cucurbitaceae family, they are also present in other plant families, as well as in some fungi and one shell-less marine mollusc. Despite the natural abundance of cucurbitacins in different natural species, their obtaining and isolation is limited, as a result, an increase in their chemical synthesis has been developed by researchers. Data on cucurbitacins and their anticancer activities wer

SUBMITTER: Varela C 

PROVIDER: S-EPMC9805216 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature