Biochemical Property Based Positional Matrix: A New Approach Towards Genome Sequence Comparison.

ABSTRACT: The growth of the genome sequence has become one of the emerging areas in the study of bioinformatics. It has led to an excessive demand for researchers to develop advanced methodologies for evolutionary relationships among species. The alignment-free methods have been proved to be more efficient and appropriate related to time and space than existing alignment-based methods for sequence analysis. In this study, a new alignment-free genome sequence comparison technique is proposed based on the biochemical properties of nucleotides. Each genome sequence can be distributed in four parameters to represent a 21-dimensional numerical descriptor using the Positional Matrix. To substantiate the proposed method, phylogenetic trees are constructed on the viral and mammalian datasets by applying the

SUBMITTER: Dey S 

PROVIDER: S-EPMC9805373 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature