Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure.

ABSTRACT: Carbonate apatite (CO₃Ap) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using CO₃Ap granules is difficult because of their granular shape. Therefore, we fabricated CO₃Ap honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of CO₃Ap HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining CO₃Ap area and calcified bone area (newly formed bone) were estimated from the histological images. CO₃Ap area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, where

SUBMITTER: Kudoh K 

PROVIDER: S-EPMC9805415 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature