Using Free-Breathing MRI to Quantify Pancreatic Fat and Investigate Spatial Heterogeneity in Children.

ABSTRACT:

Background

MRI acquisition for pediatric pancreatic fat quantification is limited by breath-holds (BH). Full segmentation (FS) or small region of interest (ROI) analysis methods may not account for pancreatic fat spatial heterogeneity, which may limit accuracy.

Purpose

To improve MRI acquisition and analysis for quantifying pancreatic proton-density fat fraction (pPDFF) in children by investigating free-breathing (FB)-MRI, characterizing pPDFF spatial heterogeneity, and relating pPDFF to clinical markers.

Study type

Prospective.

Population

A total of 34 children, including healthy (N = 16, 8 female) and overweight (N = 18, 5 female) subjects.

Field strength and sequences

3 T; multiecho gradient-echo three-dimensional (3D) stack-of-stars FB-MRI, multiecho

SUBMITTER: Story JD 

PROVIDER: S-EPMC9805469 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature