Construction and validation of a prognostic model for osteosarcoma patients based on autophagy-related genes.

ABSTRACT:

Background

Osteosarcoma is the most frequent primary bone malignancy with a poor prognosis because of pulmonary metastasis. Autophagy is strongly associated with tumor metastasis, and it is valuable to construct an autophagy-related gene risk model for predicting the prognosis of osteosarcoma.

Methods

We obtained ARGs from the Human Autophagy Database and RNA-sequencing data of osteosarcoma patients from the Gene Expression Omnibus (GEO) database. Subsequently, univariate and multivariate cox regression analyses were performed to construct a three-gene prognostic model and its accuracy was further confirmed in the Therapeutic Applications Research to Generate Effective Treatments (TARGET) database. Afterward, we detected the expression levels and effects on osteosarcoma cell

SUBMITTER: Ning B 

PROVIDER: S-EPMC9805482 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature