Global FDR control across multiple RNAseq experiments.

ABSTRACT:

Motivation

While classical approaches for controlling the false discovery rate (FDR) of RNA sequencing (RNAseq) experiments have been well described, modern research workflows and growing databases enable a new paradigm of controlling the FDR globally across RNAseq experiments in the past, present and future. The simplest analysis strategy that analyses each RNAseq experiment separately and applies an FDR correction method can lead to inflation of the overall FDR. We propose applying recently developed methodology for online multiple hypothesis testing to control the global FDR in a principled way across multiple RNAseq experiments.

Results

We show that repeated application of classical repeated offline approaches has variable control of global FDR of RNAseq experiments over

SUBMITTER: Liou L 

PROVIDER: S-EPMC9805573 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature