Borderline Resectable Pancreatic Cancer: Challenges for Clinical Management.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) remains a significant worldwide health problem with a poor prognosis. A borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC) is a tumor with limited vascular involvement that is technically resectable but with a high risk of positive margins (R1 resection).

Objective

To identify the current challenges that exist in the management of BR-PDAC.

Methods

A review of the literature was conducted to identify articles discussing the definitions and management of BR-PDAC.

Key findings

Several anatomic definitions of BR-PDAC exist, and there is significant heterogeneity in their utilization across published trials. To improve the odds of a margin negative (R0) resection, a neoadjuvant treatment approach invol

SUBMITTER: Fawaz A 

PROVIDER: S-EPMC9805723 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature