The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response.

ABSTRACT: Organisms use several strategies to mitigate mitochondrial stress, including the activation of the mitochondrial unfolded protein response (UPR^mt). The UPR^mt in Caenorhabditis elegans, regulated by the transcription factor ATFS-1, expands on this recovery program by inducing an antimicrobial response against pathogens that target mitochondrial function. Here, we show that the mammalian ortholog of ATFS-1, ATF5, protects the host during infection with enteric pathogens but, unexpectedly, by maintaining the integrity of the intestinal barrier. Intriguingly, ATF5 supports intestinal barrier function by promoting a satiety response that prevents obesity and associated hyperglycemia. This consequently averts dysregulated glucose metabolism that is detrimental to barrier fu

SUBMITTER: Chamseddine D 

PROVIDER: S-EPMC9805788 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature