Context-specific abnormalities of the central executive network in first-episode psychosis: relationship with cognition.

ABSTRACT:

Background

Cognitive impairments, which contribute to the profound functional deficits observed in psychotic disorders, have found to be associated with abnormalities in trial-level cognitive control. However, neural tasks operate within the context of sustained cognitive states, which can be assessed with 'background connectivity' following the removal of task effects. To date, little is known about the integrity of brain processes supporting the maintenance of a cognitive state in individuals with psychotic disorders. Thus, here we examine background connectivity during executive processing in a cohort of participants with first-episode psychosis (FEP).

Methods

The following fMRI study examined background connectivity of the dorsolateral prefrontal cortex (DLPFC), during w

SUBMITTER: Sarpal DK 

PROVIDER: S-EPMC9805803 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature