Differential Patterns of Change in Brain Connectivity Resulting from Severe Traumatic Brain Injury.

ABSTRACT: Background: Traumatic brain injury (TBI) damages white matter tracts, disrupting brain network structure and communication. There exists a wide heterogeneity in the pattern of structural damage associated with injury, as well as a large heterogeneity in behavioral outcomes. However, little is known about the relationship between changes in network connectivity and clinical outcomes. Materials and Methods: We utilize the rat lateral fluid-percussion injury model of severe TBI to study differences in brain connectivity in 8 animals that received the insult and 11 animals that received only a craniectomy. Diffusion tensor imaging is performed 5 weeks after the injury and network theory is used to investigate changes in white matter connectivity. Results:<

SUBMITTER: Nakuci J 

PROVIDER: S-EPMC9805864 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature