Mechanical Strain Drives Myeloid Cell Differentiation Toward Proinflammatory Subpopulations.

ABSTRACT: Objective: After injury, humans and other mammals heal by forming fibrotic scar tissue with diminished function, and this healing process involves the dynamic interplay between resident cells within the skin and cells recruited from the circulation. Recent studies have provided mounting evidence that external mechanical forces stimulate intracellular signaling pathways to drive fibrotic processes. Innovation: While most studies have focused on studying mechanotransduction in fibroblasts, recent data suggest that mechanical stimulation may also shape the behavior of immune cells, referred to as "mechano-immunomodulation." However, the effect of mechanical strain on myeloid cell recruitment and differentiation remains poorly understood and has never been investigated at the sin

SUBMITTER: Chen K 

PROVIDER: S-EPMC9805866 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature