Protein Disulfide Isomerases Function as the Missing Link Between Diabetes and Cancer.

ABSTRACT: Significance: Diabetes has long been recognized as an independent risk factor for cancer, but there is insufficient mechanistic understanding of biological mediators that bridge two disorders together. Understanding the pathogenic association between diabetes and cancer has become the focus of many studies, and findings are potentially valuable for the development of effective preventive or therapeutic strategies for both disorders. Recent Advances: A summary of literature reveals a possible connection between diabetes and cancer through the family of protein disulfide isomerase (PDI). Historical as well as the most recent findings on the structure, biochemistry, and biology of the PDI family were summarized in this review. Critical Issues: PDIs in

SUBMITTER: Jiang H 

PROVIDER: S-EPMC9805878 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature