Evaluation of a rapid susceptibility test of polymyxin B by MALDI-TOF.

ABSTRACT:

Introduction

Infections caused by multidrug-resistant microorganisms have become increasingly common in hospital environments around the world. Gram-negative bacilli stands out among multidrug-resistant bacteria mostly due to the production of carbapenemase enzymes which lead to resistance to most β-lactam antibiotics including the carbapenems. As a consequence, polymyxins have been reintroduced in the clinic as a last resort to treat infections caused by Gram-negative bacilli resistant to carbapenems. However, the only reliable method to evaluate the susceptibility to polymyxins is the broth microdilution, a laborious and time-consuming technique. Among infections caused by multidrug-resistant bacteria, bloodstream infections are the most worrisome as they can lead to sepsis and s

SUBMITTER: Barth PO 

PROVIDER: S-EPMC9806129 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature