Blood extracellular vesicles carrying synaptic function- and brain-related proteins as potential biomarkers for Alzheimer's disease.

ABSTRACT:

Introduction

Objective and accessible markers for Alzheimer's disease (AD) and other dementias are critically needed.

Methods

We identified NMDAR2A, a protein related to synaptic function, as a novel marker of central nervous system (CNS)-derived plasma extracellular vesicles (EVs) and developed a flow cytometry-based technology for detecting such plasma EVs readily. The assay was initially tested in our local cross-sectional study to distinguish AD patients from healthy controls (HCs) or from Parkinson's disease (PD) patients, followed by a validation study using an independent cohort collected from multiple medical centers (the Alzheimer's Disease Neuroimaging Initiative). Cerebrospinal fluid AD molecular signature was used to confirm diagnoses of all AD participants.

R

SUBMITTER: Tian C 

PROVIDER: S-EPMC9806186 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature