Pro-haemostatic effect of DDAVP is partially derived through non-classical (CD14^dim /CD16⁺⁺ ) monocytes residing the spleen.

ABSTRACT: The splenic endothelial Weibel-palade bodies are one of the most important candidate organelles to release von Willebrand factor upon stimulation with desmopressin. However, the presence of functional desmopressin-specific receptor has not yet been demonstrated on endothelial cells. Experimental evidences are in favour of an indirect pro-haemostatic effect of desmopressin, but the exact mediator and its cellular origin are largely elusive. Here, we report partially hampered desmopressin response in a splenectomised severe haemophilia A/Beta Thalassemia patient without any genetic variant relevant to his incomplete desmopressin response. To further investigate the role of the spleen in this phenomenon, the release of VWF from desmopressin-treated human splenic endothelial cells was assessed

SUBMITTER: Salarilak L 

PROVIDER: S-EPMC9806299 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature