The association between sleep-disordered breathing and maternal endothelial and metabolic markers in pregnancies complicated by obesity.

ABSTRACT:

Study objectives

To evaluate the impact of sleep-disordered breathing (SDB) on vascular, angiogenic and metabolic analytes in pregnancy.

Methods

Participants with a body mass index ≥30 kg/m² underwent polysomnography at 14-20 weeks gestation (visit 1). Participants with SDB (defined as an apnea-hypopnea index ≥5 events/h) were then enrolled in a separate trial. SDB-negative participants returned for a polysomnogram at 28-31 weeks (visit 2) and were recategorized as persistent-negative SDB or new-onset SDB. Mean arterial blood pressure, mean uterine artery Doppler pulsatility index, endoglin, soluble Feline McDonough Sarcoma-like tyrosine kinase 1, placental growth factor, and the homeostatic model assessment for insulin resistance were measured after each visit. O

SUBMITTER: Onslow ML 

PROVIDER: S-EPMC9806794 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature