Scaling Up Magnetic Nanobead Synthesis with Improved Stability for Biomedical Applications.

ABSTRACT: The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications motivated us to develop a scale-up protocol to increase the yield of polymeric magnetic nanobeads while aiming at keeping the structural features at optimal conditions. The protocol was applied to two different types of magnetic ferrite nanoparticles: the Mn-ferrite selected for their properties as contrast agents in magnetic resonance imaging and iron oxide nanostar shaped nanoparticles chosen for their heat performance in magnetic hyperthermia. At the same time, some experiments on surface functionalization of nanobeads with amino modified polyethyelene glycol (PEG) molecules have provided further insight into the formation mechanism of magnetic nanobeads and the

SUBMITTER: Bigall NC 

PROVIDER: S-EPMC9806829 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature