Microstates in multiple sclerosis: an electrophysiological signature of altered large-scale networks functioning?

ABSTRACT: Multiple sclerosis has a highly variable course and disabling symptoms even in absence of associated imaging data. This clinical-radiological paradox has motivated functional studies with particular attention to the resting-state networks by functional MRI. The EEG microstates analysis might offer advantages to study the spontaneous fluctuations of brain activity. This analysis investigates configurations of voltage maps that remain stable for 80-120 ms, termed microstates. The aim of our study was to investigate the temporal dynamic of microstates in patients with multiple sclerosis, without reported cognitive difficulties, and their possible correlations with clinical and neuropsychological parameters. We enrolled fifty relapsing-remitting multiple sclerosis patients and 24 health

SUBMITTER: Baldini S 

PROVIDER: S-EPMC9806850 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature